Role of the Transient Outward Current
نویسنده
چکیده
Background. Acute ischemia is known to produce more severe electrophysiological disturbances in canine ventricular epicardium than endocardium, although the mechanism for the differential sensitivity is still unresolved. Recent studies have demonstrated the presence of a prominent transient outward current (It.) in ventricular epicardium but not endocardium. The present study was designed to test the hypothesis that the differential sensitivity of these two tissues to ischemia results, at least in part, from
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جریانهای یونی کانالهای پتاسیمی و کلسیمی در سلولهای ایزوله شده عضله صاف سمینال وزیکول خوکجه و مهاراین جریانها بوسیله Glibenclamide
Smooth muscle cells of seminal vesicle exhibit excitatcry junction patential on nerve stimulation and can fire evoked) action potential (1). However) the type of ion channels that underlie this electrical activity have not been described. I have investigated the type and pharmacology of ion channel in freshly isolated smooth muscle cells from the guinea-pig seminal vesicle using whole-cell patc...
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